Article
Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor.
Genome medicine - 25 Feb 2025
Takahashi Nobuyuki, Pongor Lorinc, Agrawal Shivam P, Shtumpf Mariya, Gurjar Ankita, Rajapakse Vinodh N, Shafiei Ahmad, Schultz Christopher W, Kim Sehyun, Roame Diana, Carter Paula, Vilimas Rasa, Nichols Samantha, Desai Parth, Figg William Douglas, Bagheri Mohammad, Teif Vladimir B, Thomas Anish
Abstract excerpt
BACKGROUND: Profiling circulating cell-free DNA (cfDNA) has become a fundamental practice in cancer medicine, but the effectiveness of cfDNA at elucidating tumor-derived molecular features has not been systematically compared to standard single-lesion tumor biopsies in prospective cohorts of patients. The use of plasma instead of tissue to guide therapy is particularly attractive for patients with small cell lung...
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