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Article

Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline.

Neurobiology of aging - 1 Jul 2024

Wybitul Maha, Buchmann Andreas, Langer Nicolas, Hock Christoph, Treyer Valerie, Gietl Anton

Abstract excerpt

Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences APOE ɛ4's association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression....

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Identifiers

PMID: 38593527
DOI: 10.1016/j.neurobiolaging.2024.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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