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Article

Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study

1 Jan 2020

Abstract excerpt

INTRODUCTION: Amyloid beta (Aβ) deposition was identified to precede tau pathology and neurodegeneration in familial Alzheimer's disease (AD). But the divergence between sporadic and familial AD limits the extension of these findings to sporadic AD. METHODS: Longitudinal changes of biomarkers among different stages were assessed using linear mixed-effects models. The slopes of the models were used to estimate...

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PMID: 32793801
DOI: 10.1002/dad2.12095

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