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Article

Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories.

Neurobiology of aging - 1 Oct 2020

Lopresti Brian J, Campbell Elizabeth M, Yu Zheming, Anderson Stewart J, Cohen Ann D, Minhas Davneet S, Snitz Beth E, Royse Sarah K, Becker Carl R, Aizenstein Howard J, Mathis Chester A, Lopez Oscar L, Klunk William E, Tudorascu Dana L

Abstract excerpt

To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and longitudinal Aβ trajectories, [11C]Pittsburgh compound-B (PiB) positron emission tomography (PET) imaging was used to assess amyloid load in a clinically heterogeneous cohort of 428 elderly participants with known APOE genotype. Serial [11C]PiB data and a repeated measures model were used to model amyloid trajectories in a...

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Identifiers

PMID: 32603776
DOI: 10.1016/j.neurobiolaging.2020.05.012
PMCID: PMC7483397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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