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Article

Role of Pharmacogenomics in the Efficacy and Safety of Thiopurines in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Journal of clinical gastroenterology - 1 Aug 2023

Gutiérrez-Valencia Marta, Leache Leire, Saiz Luis Carlos, Beloqui Juan J, Barajas Miguel, Vicuña Miren, Erviti Juan

Abstract excerpt

BACKGROUND: Thiopurines' toxicity often leads to dose reduction or discontinuation. This systematic review aims to synthesize the evidence on the effect of genotype-based dosing of thiopurines on treatment efficacy and safety in inflammatory bowel disease (objective #1), and the association between genotype status and the efficacy and safety profile (objective #2). METHODS: The Cochrane Library, MEDLINE, and...

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Source

Identifiers

PMID: 36322453
DOI: 10.1097/MCG.0000000000001791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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