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Article

Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.

British journal of clinical pharmacology - 1 Nov 2020

Choi Rihwa, Lee Mi-Na, Kim Kyunga, Baek Sun-Young, Kim Tae Jun, Hong Sung Noh, Kim Young-Ho, Lee Soo-Youn

Abstract excerpt

AIMS: This study explores the effects of various genetic polymorphisms in candidate genes on thiopurine metabolism and toxicity in adult patients with Crohn's disease in Korea. METHODS: A total of 131 adult patients with Crohn's disease receiving thiopurine treatment were included. The TPMT and NUDT15 genes and an additional 116 genetic polymorphisms (in 40 genes and 3 intergenic locations) were screened for...

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Identifiers

PMID: 32372428
DOI: 10.1111/bcp.14339
PMCID: PMC7576620

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