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Article

Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan.

Journal of pharmacological sciences - 1 Nov 2023

Kakuta Yoichi, Kato Motohiro, Shimoyama Yusuke, Naito Takeo, Moroi Rintaro, Kuroha Masatake, Shiga Hisashi, Kinouchi Yoshitaka, Masamune Atsushi

Abstract excerpt

The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genotyping was approved for reimbursement in Japan in February 2019 for all indicated patients. We retrospectively examined claims data in Japan and confirmed that the proportion of patients who undergo genotyping before initiating a new thiopurine regimen has increased;...

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Identifiers

PMID: 37770157
DOI: 10.1016/j.jphs.2023.09.002

Genes

NUDT15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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