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Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

16 Oct 2015

Abstract excerpt

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects are linked to various cellular functions, which include mitochondrial activity, as well as proteasome and autophagic degradation of proteins. Remarkably, these...

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PMID: 26501339
DOI: 10.3390/biom5042675

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