Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

21 Jan 2015

Abstract excerpt

In vitro evidence suggests that the inefficient removal of damaged mitochondria by macroautophagy contributes to Parkinson's disease (PD). Using a tissue-specific gene amplification strategy, we generated a transgenic mouse line with human α-synuclein A53T overexpression specifically in dopamine (DA) neurons. Transgenic mice showed profound early-onset mitochondria abnormalities, characterized by macroautophagy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25609609
DOI: 10.1523/jneurosci.0089-14.2015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron DegenerationPMID 25609609Read ↗

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutationSemantic proximity Read ↗

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependentSemantic proximity Read ↗

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.Semantic proximity Read ↗

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Semantic proximity Read ↗

Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology.Semantic proximity Read ↗

Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1Semantic proximity Read ↗

α-Synuclein impairs macroautophagy: implications for Parkinson’s diseaseSemantic proximity Read ↗

Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.Semantic proximity Read ↗

Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.Semantic proximity Read ↗

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.Semantic proximity Read ↗

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.Semantic proximity Read ↗

Neuropathology in mice expressing human alpha-synuclein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.