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Article

The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics.

Journal of translational medicine - 9 Jun 2025

Huang Qi, Jing Yuan, Xiong Lihua, Li Lei, Feng Jingjuan, Cheng Jian

Abstract excerpt

Colorectal cancer (CRC) is a multifaceted disease influenced by genetic mutations and environmental factors, especially oxidative stress. Driver mutations are pivotal in CRC initiation and progression and alter key signaling pathways involved in cell proliferation, apoptosis, and genomic stability. Concurrently, oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and...

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Identifiers

PMID: 40490762
DOI: 10.1186/s12967-025-06640-x
PMCID: PMC12150591

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