Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4+ T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report.

doi:10.1161/ATVBAHA.123.320409

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Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4+ T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2024

Takeda Shintaro, Emoto Takuo, Yamashita Tomoya, Yamamoto Hiroyuki, Takaya Tomofumi, Sawada Takahiro, Yoshida Takeshi, Inoue Masatoshi, Suzuki Yuya, Hamana Tomoyo, Inoue Taishi, Taniguchi Masayuki, Sasaki Naoto, Otake Hiromasa, Ohkawa Takenao, Furuyashiki Tomoyuki, Kawai Hiroya, Hirata Ken-Ichi

Abstract excerpt

BACKGROUND: Acute coronary syndrome (ACS) involves plaque-related thrombosis, causing primary ischemic cardiomyopathy or lethal arrhythmia. We previously demonstrated a unique immune landscape of myeloid cells in the culprit plaques causing ACS by using single-cell RNA sequencing. Here, we aimed to characterize T cells in a single-cell level, assess clonal expansion of T cells, and find a therapeutic target to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38572648
DOI: 10.1161/ATVBAHA.123.320409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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