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DNA Methylation Regulator-Meditated Modification Patterns Define the Distinct Tumor Microenvironment in Lung Adenocarcinoma

6 Sept 2021

Abstract excerpt

BACKGROUND: Epigenetic changes of lung adenocarcinoma (LUAD) have been reported to be a relevant factor in tumorigenesis and cancer progression. However, the molecular mechanisms responsible for DNA methylation patterns in the tumor immune-infiltrating microenvironment and in cancer immunotherapy remain unclear. METHODS: We conducted a global analysis of the DNA methylation modification pattern (DMP) and immune...

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PMID: 34552879
DOI: 10.3389/fonc.2021.734873

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