Characterization of m6A RNA Methylation Regulators Predicts Survival and Immunotherapy in Lung Adenocarcinoma.

doi:10.3389/fimmu.2021.782551

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Article

Characterization of m6A RNA Methylation Regulators Predicts Survival and Immunotherapy in Lung Adenocarcinoma.

Frontiers in immunology - 1 Jan 2021

Zhu Minggao, Cui Yachao, Mo Qi, Zhang Junwei, Zhao Ting, Xu Yujie, Wu Zhenpeng, Sun Donglin, Zhang Xiaoren, Li Yingchang, You Qiang

Abstract excerpt

N6-methyladenosine (m6A) RNA modification is a reversible mechanism that regulates eukaryotic gene expression. Growing evidence has demonstrated an association between m6A modification and tumorigenesis and response to immunotherapy. However, the overall influence of m6A regulators on the tumor microenvironment and their effect on the response to immunotherapy in lung adenocarcinoma remains to be explored. Here,...

Topics

Adenocarcinoma of Lung
Adenosine
Biomarkers, Tumor
Computational Biology
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunomodulation
Immunotherapy
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylation

Models, Biological

Mutation

Neoplasm Grading

Neoplasm Staging

Prognosis

RNA, Messenger

Treatment Outcome

Source

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Identifiers

PMID: 34975871
DOI: 10.3389/fimmu.2021.782551
PMCID: PMC8718692

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