Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2024

Lee Sanghun, Hecker Julian, Hahn Georg, Mullin Kristina, Lutz Sharon M, Tanzi Rudolph E, Lange Christoph, Prokopenko Dmitry

Abstract excerpt

INTRODUCTION: Genome-wide association studies have identified numerous disease susceptibility loci (DSLs) for Alzheimer's disease (AD). However, only a limited number of studies have investigated the dependence of the genetic effect size of established DSLs on genetic ancestry. METHODS: We utilized the whole genome sequencing data from the Alzheimer's Disease Sequencing Project (ADSP) including 35,569...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein C-I

Share to Apolipoproteins E

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38563508
DOI: 10.1002/alz.13796
PMCID: PMC11095441

Genes

APOE
APOC1
TOMM40
SIPA1L2
SLC24A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.PMID 38563508Read ↗

Biobank-scale characterization of Alzheimer’s disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestriesSemantic proximity Read ↗

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project.Semantic proximity Read ↗

Assessment of common genetic variation in Alzheimer’s and Parkinson’s diseases reveals global distinction in population attributable riskSemantic proximity Read ↗

Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection.Semantic proximity Read ↗

Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.Semantic proximity Read ↗

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.Semantic proximity Read ↗

Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing ProjectSemantic proximity Read ↗

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer’s Disease in individuals of African ancestrySemantic proximity Read ↗

New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Semantic proximity Read ↗

Differences in the frequency of Alzheimer's disease-associated genomic variations in populations of different races.Semantic proximity Read ↗

The effect of Alzheimer’s disease-associated genetic variants on longevitySemantic proximity Read ↗

Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.