Article
Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype.
Nature communications - 30 Mar 2024
Chen Han-Yi, Hsieh Wan-Chen, Liu Yu-Chieh, Li Huei-Ying, Liu Po-Yo, Hsu Yu-Ting, Hsu Shao-Chun, Luo An-Chi, Kuo Wei-Chen, Huang Yi-Jhen, Liou Gan-Guang, Lin Meng-Yun, Ko Chun-Jung, Tsai Hsing-Chen, Chang Shu-Jung
Abstract excerpt
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory phenotype (SASP) by damaging mitochondrial DNA. The actions of typhoid toxin disrupt mitochondrial DNA integrity, leading to mitochondrial dysfunction and disturbance of redox homeostasis. Consequently, it...
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