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Bacterial genotoxins induce T cell senescence

1 Jun 2021

Abstract excerpt

Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear. To address this issue, we investigated the effects of the most widely expressed bacterial genotoxin, the cytolethal distending toxin (CDT), on T cells-the...

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PMID: 34107253
DOI: 10.1016/j.celrep.2021.109220

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