Article
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
Nucleic acids research - 1 Jan 2014
Rulten Stuart L, Rotheray Amy, Green Ryan L, Grundy Gabrielle J, Moore Duncan A Q, Gómez-Herreros Fernando, Hafezparast Majid, Caldecott Keith W
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS). FUS is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins that bind thousands of pre-mRNAs and can regulate their splicing. Here,...
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