Article

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

2021-01-08

Abstract excerpt

<h4>SUMMARY</h4> Fused in sarcoma/translated in liposarcoma (FUS) is a causative gene of amyotrophic lateral sclerosis (ALS). Mutated FUS causes accumulation of DNA damage and cytosolic stress granule (SG) formation, thereby motor neuron (MN) death. However, key molecular aetiology remains unclear. Here, we applied a novel platform technology, iBRN, “Non-biased” B ayesian gene regulatory n etwork analysis based...

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Literature Corpus work: 0c7e710b-61e8-5ca8-8b7d-86eb450cba58
DOI: 10.1101/2021.01.07.425798

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