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Article

An in-silico analysis of OGT gene association with diabetes mellitus.

BMC research notes - 27 Mar 2024

Ayodele Abigail O, Udosen Brenda, Oluwagbemi Olugbenga O, Oladipo Elijah K, Omotuyi Idowu, Isewon Itunuoluwa, Nash Oyekanmi, Soremekun Opeyemi, Fatumo Segun

Abstract excerpt

O-GlcNAcylation is a nutrient-sensing post-translational modification process. This cycling process involves two primary proteins: the O-linked N-acetylglucosamine transferase (OGT) catalysing the addition, and the glycoside hydrolase OGA (O-GlcNAcase) catalysing the removal of the O-GlCNAc moiety on nucleocytoplasmic proteins. This process is necessary for various critical cellular functions. The O-linked...

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PMID: 38539217
DOI: 10.1186/s13104-024-06744-5
PMCID: PMC10976716

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