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Article

Genetic insights into obesity: in silico identification of pathogenic SNPs in MBOAT4 gene and their structural molecular dynamics consequences.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Azmi Muhammad Bilal, Sehgal Sheikh Arslan, Asif Uzma, Musani Sarah, Abedin Mariam Farhan Essa, Suri Azeema, Ahmed Syed Danish Haseen, Qureshi Shamim Akhtar

Abstract excerpt

Membrane Bound O-Acyltransferase Domain-Containing 4 (MBOAT4) protein catalyzes ghrelin acylation, leading to prominent ghrelin activity, hence characterizing its role as an anti-obesity target. We extracted 625 exonic SNPs from the ENSEMBL database and one phenotype-based missense mutation associated with obesity (A46T) from the HGMD (Human Gene Mutation Database). These were differentiated on deleterious...

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Source

Identifiers

PMID: 37921712
DOI: 10.1080/07391102.2023.2274970

Genes

MBOAT4
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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