Article
Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2).
Theranostics - 1 Jan 2014
George Doss C Priya, Chakraborty Chiranjib, Haneef S A Syed, Nagasundaram Nagarajan, Chen Luonan, Zhu Hailong
Abstract excerpt
Heterozygous mutations in the central glycolytic enzyme glucokinase (GCK) can result in an autosomal dominant inherited disease, namely maturity-onset diabetes of the young, type 2 (MODY 2). MODY 2 is characterised by early onset: it usually appears before 25 years of age and presents as a mild form of hyperglycaemia. In recent years, the number of known GCK mutations has markedly increased. As a result,...
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