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Article

First comprehensive in silico analysis of the functional and structural consequences of SNPs in human GalNAc-T1 gene.

Computational and mathematical methods in medicine - 1 Jan 2014

Mohamoud Hussein Sheikh Ali, Hussain Muhammad Ramzan Manwar, El-Harouni Ashraf A, Shaik Noor Ahmad, Qasmi Zaheer Ulhaq, Merican Amir Feisal, Baig Mukhtiar, Anwar Yasir, Asfour Hani, Bondagji Nabeel, Al-Aama Jumana Yousuf

Abstract excerpt

GalNAc-T1, a key candidate of GalNac-transferases genes family that is involved in mucin-type O-linked glycosylation pathway, is expressed in most biological tissues and cell types. Despite the reported association of GalNAc-T1 gene mutations with human disease susceptibility, the comprehensive computational analysis of coding, noncoding and regulatory SNPs, and their functional impacts on protein level, still...

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Identifiers

PMID: 24723968
DOI: 10.1155/2014/904052
PMCID: PMC3960557

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