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Concordance of targeted and whole genome sequencing for Mycobacterium tuberculosis genotypic drug susceptibility testing.

Diagnostic microbiology and infectious disease - 1 Jun 2024

Cloutier Charette William, Rabodoarivelo Marie-Sylvianne, Point Floriane, Knoblauch Astrid M, Andrianomanana Fanantenana Randria, Hall Michael B, Iqbal Zamin, Supply Philip, Martin Anandi, Rakotosamimanana Niaina, Grandjean Lapierre Simon

Abstract excerpt

Targeted Next Generation Sequencing (tNGS) and Whole Genome Sequencing (WGS) are increasingly used for genotypic drug susceptibility testing (gDST) of Mycobacterium tuberculosis. Thirty-two multi-drugs resistant and 40 drug susceptible isolates from Madagascar were tested with Deeplex® Myc-TB and WGS using the Mykrobe analysis pipeline. Sixty-four of 72 (89 %) yielded concordant categorical gDST results for drugs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38537504
DOI: 10.1016/j.diagmicrobio.2024.116249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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