Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted and whole-genome sequencing for drug resistance and genetic relatedness inference of rifampicin-resistant Mycobacterium tuberculosis : an in-depth comparison

11 Sept 2025

Abstract excerpt

Background Challenges in tuberculosis (TB) control have fuelled interest in routine next generation sequencing (NGS). However, the comparative performance of targeted NGS (tNGS) and whole genome sequencing (WGS) for drug resistance and genetic relatedness inference remains unclear. Methods In this cross-sectional study, we compared WGS (MICK-MAGMA platform) and the Deeplex MycTB tNGS assay in 90 patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diagnosis and treatment of tuberculosis
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41736736
DOI: 10.1183/23120541.00630-2025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted and whole-genome sequencing for drug resistance and genetic relatedness inference of rifampicin-resistant Mycobacterium tuberculosis : an in-depth comparisonPMID 41736736Read ↗

Analytical concordance of targeted next-generation sequencing and whole-genome sequencing for <i>Mycobacterium tuberculosis</i> drug resistance and lineage determination in West Java, IndonesiaSemantic proximity Read ↗

An overview of next generation sequencing strategies and genomics tools used for tuberculosis researchSemantic proximity Read ↗

Implementation of Whole Genome Sequencing of Tuberculosis Isolates in a Referral Center in Rome: Six Years’ Experience in Characterizing Drug-Resistant TB and Disease TransmissionSemantic proximity Read ↗

Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia.Semantic proximity Read ↗

Whole genome sequencing of Mycobacterium tuberculosis for detection of drug resistance: a systematic review.Semantic proximity Read ↗

Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the FieldSemantic proximity Read ↗

Mycobacterium tuberculosis Next-Generation Whole Genome Sequencing: Opportunities and ChallengesSemantic proximity Read ↗

TB-Genaly: A multicenter evaluated whole genome sequencing pipeline for tuberculosis drug resistance assessment and transmission analysis.Semantic proximity Read ↗

Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Drug Resistance: A Retrospective Observational Study in Eastern ChinaSemantic proximity Read ↗

Direct detection of drug-resistant Mycobacterium tuberculosis using targeted next generation sequencingSemantic proximity Read ↗

The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samplesSemantic proximity Read ↗

Targeted next-generation sequencing for comprehensive diagnosis and drug resistance detection in pulmonary and extrapulmonary tuberculosis: a single-center retrospective study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.