Article
Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study.
Nature communications - 26 Mar 2024
Tissink E P, Shadrin A A, van der Meer D, Parker N, Hindley G, Roelfs D, Frei O, Fan C C, Nagel M, Nærland T, Budisteanu M, Djurovic S, Westlye L T, van den Heuvel M P, Posthuma D, Kaufmann T, Dale A M, Andreassen O A
Abstract excerpt
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better understanding of pleiotropy across modalities could inform us on the integration of brain function, micro- and macrostructure. Here we show extensive genetic overlap across neuroimaging modalities at a locus...
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