Article

Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia

2021-02-02

Abstract excerpt

Mutations in SET binding protein 1 (SETBP1) are associated with poor outcomes in myeloid leukemias. In the Ras-driven leukemia, juvenile myelomonocytic leukemia, SETBP1 mutations are enriched in relapsed disease. While some mechanisms for SETBP1-driven oncogenesis have been established, it remains unclear how SETBP1 specifically modulates the biology of Ras-driven leukemias. In this study, we found that when co-ex...

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Literature Corpus work: 304685cc-a9b1-589d-adce-1b2aca89a115
DOI: 10.1101/2021.02.01.429244

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