Article
Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm.
Leukemia - 1 Mar 2019
Kong Guangyao, You Xiaona, Wen Zhi, Chang Yuan-I, Qian Shuiming, Ranheim Erik A, Letson Christopher, Zhang Xinmin, Zhou Yun, Liu Yangang, Rajagopalan Adhithi, Zhang Jingfang, Stieglitz Elliot, Loh Mignon, Hofmann Inga, Yang David, Zhong Xuehua, Padron Eric, Zhou Lan, Pear Warren S, Zhang Jing
Abstract excerpt
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in human T-cell leukemia, while loss of Notch signaling is reported in myeloid leukemias. Here, we report a novel oncogenic function of Notch signaling in oncogenic...
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