Article

Targetable leukemia dependency on noncanonical PI3Kγ signaling

2023-12-15

Abstract excerpt

Phosphoinositide 3-kinase gamma (PI3Kγ) is implicated as a target to repolarize tumor-associated macrophages and promote anti-tumor immune responses in solid cancers. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening with functional analyses across acute leukemias, we define a selective dependency on the PI3Kγ complex in a high-risk s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a9e3533-9273-5885-969d-52cd5344437f
DOI: 10.1101/2023.12.15.571909

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targetable leukemia dependency on noncanonical PI3Kγ signalingDOI 10.1101/2023.12.15.571909Read

Outlook on PI3K/AKT/mTOR inhibition in acute leukemiaSemantic proximity Read

Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cellsSemantic proximity Read

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.Semantic proximity Read

Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitorsSemantic proximity Read

Phosphoinositide 3′-kinase delta: turning off BCR signaling in Chronic Lymphocytic LeukemiaSemantic proximity Read

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activationSemantic proximity Read

A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITDSemantic proximity Read

Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic, and transcriptomic comparison.Semantic proximity Read

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.Semantic proximity Read

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML.Semantic proximity Read

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphomaSemantic proximity Read

Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem CellsSemantic proximity Read