Article
ENPP2/Autotaxin: The potential drug target for alcoholic liver disease identified through Mendelian randomization analysis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2024
Luo Peiqiong, Yu Xuefeng
Abstract excerpt
BACKGROUND AND AIMS: At present, there is still a lack of radical drug targets for intervention in alcoholic liver disease (ALD), and drug discovery through randomized controlled trials is a lengthy, risky, and expensive undertaking, so we aimed to identify effective drug targets based on human genetics. METHODS: We used Mendelian randomization (MR) and Bayesian colocalization analysis to investigate 2639 genes...
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