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Article

Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes-Related Therapeutic Targets for Obesity.

Journal of cellular and molecular medicine - 1 May 2026

Zhang Xingjian, Tian Yong, Ren Xiaoying, Tian Juan, Liu Jia, Wang Guang

Abstract excerpt

Weight-loss treatment is crucial for individuals with obesity to prevent various complications. The role of Immune cells in obesity has been recently recognized, whereas its translation into therapy requires identifying key target genes. We performed Mendelian randomization (MR) analysis to assess causal relationships between expression quantitative trait loci (eQTL) of 14 immune cells and obesity-related traits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42117609
DOI: 10.1111/jcmm.71185
PMCID: PMC13162345

Genes

PYGB
CD4
FNBP4
PRUNE1
UBE2Z
ZCCHC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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