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Article

Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study.

Scientific reports - 3 Oct 2024

Zheng Zhen, Chen Dahua, Lv Jiaming, Du Juan, Liu Kaitai

Abstract excerpt

Autoimmune hepatitis(AIH) is a chronic progressive inflammatory liver disease induced by loss of immune tolerance. The role of circulating metabolites in disease pathogenesis is unclear. This study aimed to investigate potential causal links between plasma metabolites and AIH risk by employing a two-sample Mendelian randomization approach. A comprehensive bidirectional two-sample Mendelian randomization analysis...

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Genome-Wide Association Study
Hepatitis, Autoimmune
Kynurenine
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39362997
DOI: 10.1038/s41598-024-74387-4
PMCID: PMC11449928

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