Article
A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease.
Frontiers in immunology - 1 Jan 2025
Zhou Qingyi, Ma Xuan, Cui Qianqian, Zhang Lei, Yao Chao, Zhang Zilu, Wang Xiaoli, Chu Liang
Abstract excerpt
Background: Alcohol-associated liver disease (ALD) constitutes a global health crisis, yet the molecular mechanisms driving its pathogenesis remain unresolved, critically impeding the development of effective therapeutics. A fundamental challenge is the differentiation of correlational biomarkers from the causal drivers of disease. Here, we perform a systematic characterization of the ALD causal proteome to...
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