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Article

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders.

Canadian journal of gastroenterology & hepatology - 1 Jan 2025

Shi Shuyi, Liu Minghui, Gao Haonan, Liu Fang, Song Yuhu

Abstract excerpt

Background: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that is commonly associated with various other autoimmune disorders. We conducted a phenome-wide association study Mendelian randomization (MR-PheWAS) to determine genetic association between PBC and other diseases, particularly autoimmune disorders. Methods: We performed a PheWAS to investigate the causal associations between PBC...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40727246
DOI: 10.1155/cjgh/1716853
PMCID: PMC12301091

Genes

CCDC88B
MMEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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