Article
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
2023-09-26
Abstract excerpt
<title>Abstract</title> <p>Senescent cells accumulate in organisms over time because of tissue damage and impaired immune surveillance and contribute to age-related tissue decline<sup>1,2</sup>. In agreement, genetic ablation studies reveal that elimination of senescent cells from aged tissues can ameliorate various age-related pathologies, including metabolic dysfunction and decreased physical fitness<sup>3-7</s...
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Identifiers and source
- Literature Corpus work
- 66caf3fe-c3cb-57ea-ab73-1e5730d02d18
- DOI
- 10.21203/rs.3.rs-3385749/v1