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Article

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy.

PLoS pathogens - 1 Nov 2022

Shahid Aniqa, Jones Bradley R, Yang Julia S W, Dong Winnie, Shaipanich Tawimas, Donohoe Kathryn, Brumme Chanson J, Joy Jeffrey B, Leung Janice M, Brumme Zabrina L

Abstract excerpt

The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral sequences (nef) by single-genome approaches from blood and lung from nine individuals on long-term suppressive antiretroviral therapy (ART), and characterized genetic diversity and compartmentalization using formal tests. Consistent with clonal expansion as a driver of HIV persistence, identical sequences comprised between 8%...

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Identifiers

PMID: 36331974
DOI: 10.1371/journal.ppat.1010613
PMCID: PMC9668181

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Source receipt: pubmed, retrieved 7 Sept 2026.

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