Article
Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy.
Journal of virology - 14 Feb 2020
Jones Bradley R, Miller Rachel L, Kinloch Natalie N, Tsai Olivia, Rigsby Hawley, Sudderuddin Hanwei, Shahid Aniqa, Ganase Bruce, Brumme Chanson J, Harris Marianne, Poon Art F Y, Brockman Mark A, Fromentin Rémi, Chomont Nicolas, Joy Jeffrey B, Brumme Zabrina L
Abstract excerpt
The HIV reservoir, which comprises diverse proviruses integrated into the genomes of infected, primarily CD4+ T cells, is the main barrier to developing an effective HIV cure. Our understanding of the genetics and dynamics of proviruses persisting within distinct CD4+ T cell subsets, however, remains incomplete. Using single-genome amplification, we characterized subgenomic proviral sequences (nef region) from...
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