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Genotype-phenotype interaction in Alzheimer's disease immune activation.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2026

Knudtzon Stephanie, Kirsebom Bjørn-Eivind, Pålhaugen Lene, Bettella Francesco, Gísladóttir Berglind, Bahrami Shahram, Athanasiu Lavinia, Rongve Arvid, Nakling Arne, Almdahl Ina S, Kalheim Lisa, Jarholm Jonas Alexander, Grøntvedt Gøril Rolfseng, Skogseth Ragnhild Eide, Aarsland Dag, Waterloo Knut, Andreassen Ole A, Fladby Tormod, Nordengen Kaja

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder influenced by genetic factors, particularly related to immune activation. This study examines genotype-phenotype interactions affecting immune responses in AD as a reaction to neurodegeneration. METHODS: We computed AD polygenic risk scores (PRSs) informed by shared AD-autoimmunity genetics (AD PRSINFL), AD-independent immune activation score...

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PMID: 41517952
DOI: 10.1002/alz.70978
PMCID: PMC12789877

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