Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic targeting at genome mutations of liver cancer by the insertion of HSV1 thymidine kinase through Cas9-mediated editing.

Hepatology communications - 1 Apr 2024

Kader Muhamuda, Sun Wei, Ren Bao-Guo, Yu Yan-Ping, Tao Junyan, Foley Lesley M, Liu Silvia, Monga Satdarshan P, Luo Jian-Hua

Abstract excerpt

BACKGROUND: Liver cancer is one of the most lethal malignancies for humans. The treatment options for advanced-stage liver cancer remain limited. A new treatment is urgently needed to reduce the mortality of the disease. METHODS: In this report, we developed a technology for mutation site insertion of a suicide gene (herpes simplex virus type 1- thymidine kinase) based on type II CRISPR RNA-guided endonuclease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catenins
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

Share to Liver Neoplasms

Share to Mutation

Share to Thymidine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 38497929
DOI: 10.1097/HC9.0000000000000412
PMCID: PMC10948134

Genes

SAFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic targeting at genome mutations of liver cancer by the insertion of HSV1 thymidine kinase through Cas9-mediated editing.PMID 38497929Read ↗

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.Semantic proximity Read ↗

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas.Semantic proximity Read ↗

Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement.Semantic proximity Read ↗

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancerSemantic proximity Read ↗

The chicken chorioallantoic membrane model for isolation of CRISPR/cas9-based HSV-1 mutant expressing tumor suppressor p53Semantic proximity Read ↗

CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized miceSemantic proximity Read ↗

Genetically Engineered Mouse Models for Liver CancerSemantic proximity Read ↗

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1Semantic proximity Read ↗

Base editing of the mutated TERT promoter inhibits liver tumor growth.Semantic proximity Read ↗

An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation.Semantic proximity Read ↗

Short-Term and Highly Efficient Cas9 Expression System Using Adenovirus Vector and Site-Specific Recombinase CreSemantic proximity Read ↗

Quadruple-editing of MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.