Article

Quadruple-editing of MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells

2021-02-24

Abstract excerpt

<h4>Background: </h4> Mutated KRAS promotes the activation of mitogen-activated protein kinase (MAPK) pathway and the progression of colorectal cancer (CRC) cells. Aberrant activation of phosphatidylinositol 3‑kinase (PI3K) pathway strongly attenuates the efficacy of MAPK suppression in KRAS-mutated CRC cells. The development of a novel strategy targeting dual-pathway is therefore highly essential for the therapy...

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Literature Corpus work: 33931675-c258-55a1-a665-79a86315e65c
DOI: 10.21203/rs.3.rs-230629/v1

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