Article
Base editing of the mutated TERT promoter inhibits liver tumor growth.
Hepatology (Baltimore, Md.) - 1 Jun 2024
Zhao Gaoxiang, Ma Qingxia, Yang Huang, Jiang Hongfei, Xu Qianqian, Luo Shudi, Meng Zhaoyuan, Liu Juanjuan, Zhu Lei, Lin Qian, Li Min, Fang Jing, Ma Leina, Qiu Wensheng, Mao Zhengwei, Lu Zhimin
Abstract excerpt
BACKGROUND AND AIMS: Base editing has shown great potential for treating human diseases with mutated genes. However, its potential for treating HCC has not yet been explored. APPROACH AND RESULTS: We employed adenine base editors (ABEs) to correct a telomerase reverse transcriptase ( TERT ) promoter mutation, which frequently occurs in various human cancers, including HCC. The mutated TERT promoter -124 C>T is...
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