Article

The chicken chorioallantoic membrane model for isolation of CRISPR/cas9-based HSV-1 mutant expressing tumor suppressor p53

2023-05-12

Abstract excerpt

Oncolytic viruses (OVs) have emerged as a novel cancer treatment modality, which selectively target and kill cancer cells while sparing normal ones. Among them, engineered Herpes Simplex Virus type 1 has been proposed to be employed as a potential treatment of cancer and was moved to phase III clinical trials. In this study, to improve oncoselectivity and oncotoxicity properties, the UL39 gene of the ICP34.5 delet...

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Literature Corpus work: 59851ae7-a4c6-519f-8bf6-98bb10b5efef
DOI: 10.1101/2023.05.12.540548

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