Article

Viral replication and interferon responses in bronchial epithelia is enhanced by Th17 cells

2025-10-12

Abstract excerpt

<h4>Rationale</h4> The impact of Th17 lymphocytes on epithelial responses to rhinovirus infection in asthma is poorly characterized. <h4>Methods</h4> Bronchial epithelial cells (BECs) from children with asthma were differentiated to an organotypic epithelium and primed via co-culture with healthy donor Th17 lymphocytes for 4 days prior to apical infection with human rhinovirus-16 (RV-16). RNA sequencing with WGC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f949922-6659-559c-8e86-b7e507846dd7
DOI: 10.1101/2025.10.10.681711

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Viral replication and interferon responses in bronchial epithelia is enhanced by Th17 cellsDOI 10.1101/2025.10.10.681711Read

IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial EpitheliumSemantic proximity Read

Unique nasal cell states induced by common pediatric respiratory virusesSemantic proximity Read

Human Rhinovirus 16 impacts cilia structure in 3D cultured primary bronchial epithelial tissue through alternative splicing of host cilia RNAsSemantic proximity Read

Human rhinovirus 16 infection modifies the microRNA landscape during epithelial cell infectionSemantic proximity Read

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSemantic proximity Read

Airway IRF7 <sup>hi</sup> versus IRF7 <sup>lo</sup> molecular response patterns determine clinical phenotypes in children with acute wheezingSemantic proximity Read

Airway epithelial response to RSV is impaired in multiciliated and goblet cells in asthmaSemantic proximity Read

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic FibrosisSemantic proximity Read

Rhinovirus Induces Airway Epithelial Gene Expression through Double-Stranded RNA and IFN-Dependent PathwaysSemantic proximity Read

Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory IllnessesSemantic proximity Read

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of AsthmaSemantic proximity Read

Association between polymorphisms on chromosome 17q12-q21 and rhinovirus-induced interferon responses.Semantic proximity Read