Article

Airway IRF7 <sup>hi</sup> versus IRF7 <sup>lo</sup> molecular response patterns determine clinical phenotypes in children with acute wheezing

2017-11-21

Abstract excerpt

<h4>Summary</h4> Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7 hi versus IRF7 lo molecular phenotypes, the former exhibiting robust upregulation of Th1/type I interferon responses and the latter an alternative signatu...

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Literature Corpus work: a8b6432c-55ce-5993-ac8b-39ba8bc58eca
DOI: 10.1101/222950

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