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Article

IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Feb 2018

Landgraf-Rauf Katja, Boeck Andreas, Siemens Diana, Klucker Elisabeth, Vogelsang Vanessa, Schmidt Susanne, Kunze Sonja, Weissenbacher Claudia, Graessel Anke, Schmidt-Weber Carsten, von Mutius Erika, Schedel Michaela, Schaub Bianca

Abstract excerpt

BACKGROUND: Allergic and non-allergic childhood asthma has been characterized by distinct immune mechanisms. While interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) influence atopy risk, the effect of SNPs on asthma phenotype-specific immune mechanisms is unclear. We assessed whether IRF-1 SNPs modify distinct immune-regulatory pathways in allergic and non-allergic childhood asthma (AA/NA). METHODS: In...

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Identifiers

PMID: 29047170
DOI: 10.1111/pai.12821

Genes

ICAM3
NOD2
RGS13
RORC
TSC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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