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Article

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

11 Feb 2019

Abstract excerpt

Abstract Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7hi versus IRF7lo molecular phenotypes, the former exhibiting robust upregulation of Th1/type I IFN responses and the latter an alternative signature marked by...

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Asthma and respiratory diseases
IL-33, ST2, and ILC Pathways
Respiratory viral infections research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30745463
DOI: 10.4049/jimmunol.1800178

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