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Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma.

Cell genomics - 11 Sept 2024

Djeddi Sarah, Fernandez-Salinas Daniela, Huang George X, Aguiar Vitor R C, Mohanty Chitrasen, Kendziorski Christina, Gazal Steven, Boyce Joshua A, Ober Carole, Gern James E, Barrett Nora A, Gutierrez-Arcelus Maria

Abstract excerpt

Asthma is a complex disease caused by genetic and environmental factors. Studies show that wheezing during rhinovirus infection correlates with childhood asthma development. Over 150 non-coding risk variants for asthma have been identified, many affecting gene regulation in T cells, but the effects of most risk variants remain unknown. We hypothesized that airway epithelial cells could also mediate genetic...

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Asthma
COVID-19
Epithelial Cells
Influenza, Human
Picornaviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39197446
DOI: 10.1016/j.xgen.2024.100636
PMCID: PMC11480861

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