Article
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma.
Mucosal immunology - 1 Aug 2024
Niese Michelle L, Pajulas Abigail L, Rostron Cameron R, Cheung Cherry C L, Krishnan Maya S, Zhang Jilu, Cannon Anthony M, Kaplan Mark H
Abstract excerpt
Multi-cytokine-producing Th9 cells secrete IL-9 and type 2 cytokines and mediate mouse and human allergic inflammation. However, the cytokines that promote a multi-cytokine secreting phenotype have not been defined. Tumor necrosis factor superfamily member TL1A signals through its receptor DR3 to increase IL-9. Here we demonstrate that TL1A increases expression of IL-9 and IL-13 co-expressing cells in murine Th9...
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