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Article

Human TH9 differentiation is dependent on signal transducer and activator of transcription (STAT) 3 to restrain STAT1-mediated inhibition.

The Journal of allergy and clinical immunology - 1 Mar 2019

Zhang Yuan, Siegel Andrea M, Sun Guangping, Dimaggio Tom, Freeman Alexandra F, Milner Joshua D

Abstract excerpt

BACKGROUND: Patients with loss-of-function (LOF) signal transducer and activator of transcription 3 (STAT3) mutations have dermatitis, enhanced IgE production despite a relative lack of immediate hypersensitivity, recurrent infection, and an increased rate of lymphoma in addition to a number of skeletal and connective tissue abnormalities. Patients with STAT1 gain-of-function (GOF) mutations also have...

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Source

Identifiers

PMID: 30030006
DOI: 10.1016/j.jaci.2018.06.036

Genes

STAT3
STAT1

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