Article

TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease

2024-02-12

Abstract excerpt

<h4>Objective: </h4> Death receptor 3 (DR3) and its ligand tumor necrosis factor like ligand 1A (TL1A), are involved in the regulation of the balance between effector and regulatory T cells in IBD. New evidence suggests a role of IL-9-secreting Th9 cells in the pathogenesis of ulcerative colitis (UC), although the molecular pathways through which IL-9 and Th9 cells may mediate intestinal inflammation in Crohn's di...

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Identifiers and source

Literature Corpus work: 41feb124-7c0b-53de-8251-ea39cea5dc98
DOI: 10.1101/2024.02.09.579684

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