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Article

The locus ceruleus norepinephrine system

16 Nov 2009

Abstract excerpt

IL-9–producing Th cells, termed Th9 cells, contribute to immunity against parasites and cancers but have detrimental roles in allergic disease and colitis. Th9 cells differentiate in response to IL-4 and TGF-β, but these signals are insufficient to drive Th9 differentiation in the absence of IL-2. IL-2–induced STAT5 activation is required for chromatin accessibility within Il9 enhancer and promoter regions and...

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PMID: 19917994
DOI: 10.1212/wnl.0b013e3181c2937c

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